Background: Nurses frequently experience physical and psychological burnout due to continuous interactions not only with patients and their families but also with various healthcare professionals. Burnout can negatively impact patient care and lead to turnover, making it crucial to identify factors contributing to nurse burnout.Methods: This study is a descriptive correlational study aimed at examining the effects of nurses’ role conflict, emotional labor, and resilience on burnout. Data collection occurred between July 8 and July 21, 2024, from 134 nurses with at least six months of clinical experience. A structured questionnaire measured role conflict, emotional labor, resilience, and burnout. Statistical analyses included descriptive statistics, independent t-tests, ANOVA, Pearson correlation, and stepwise multiple regression using SPSS 25.0.Results: Burnout significantly differed by age, work department, and job satisfaction. Nurses in their 30s, those working in general wards or special units, and those with lower job satisfaction showed higher burnout levels. Job satisfaction, resilience, role conflict, emotional labor, and work department were identified as significant factors associated with burnout.Conclusions: Burnout among nurses is influenced by personal and work-related factors. Strategies to enhance resilience and job satisfaction, along with efforts to reduce emotional labor and role conflict, are essential to prevent and manage burnout and support nurses’ well-being.